Open AccessFosfomycin susceptibility among ESBL producing gram negative bacilli causing urinary tract infections
Author(s) -
K. Rajeshwari
Publication year - 2021
Publication title -
indian journal of microbiology research
Language(s) - English
Resource type - Journals
eISSN - 2394-5478
pISSN - 2394-546X
DOI - 10.18231/j.ijmr.2021.029
Subject(s) - fosfomycin , antibiotics , microbiology and biotechnology , klebsiella pneumoniae , urinary system , medicine , multiple drug resistance , drug resistance , bacilli , biology , bacteria , escherichia coli , biochemistry , genetics , gene
Urinary tract infection is one of the common infection encountered in day to day practice. Due to emergence of drug resitance among uropathogens treatment options have become limited. Fosfomycin being a safe oral antibiotic is being used widely to treat multidrug resistant uropathogens. In the present study 831 (48.45%) samples that yielded significant growth were processed out of 1715 sample for ESBL detection by double disc synergy and phenotypic confirmatory method. E.coli constituted the predominant isolate (60.4%) followed by K.pneumoniae. 256 (30.80%) samples yielding growth were from out patients and 575 from inpatients. Over all 44% of isolates in the present study were ESBL producers. 50% of Ecoli were ESBL producers. 70.64% of ESBL isolates were susceptible to fosfomycin in vitro. Present study finding suggest that resistance to fosfomysin is on rise even though majority of ESBLs were sensitive to it. The current study recommends to use fosfomycin only after testing susceptibility among uropathogens.