Open AccessCovid-19 vaccine breakthrough infections amongst health care workers in a tertiary care centre
Author(s) -
Liz Mary Paul,
M Shamsudeen
Publication year - 2022
Publication title -
ip international journal of medical microbiology and tropical diseases/ip international journal of medical microbiology and tropical diseases
Language(s) - English
Resource type - Journals
eISSN - 2581-4761
pISSN - 2581-4753
DOI - 10.18231/j.ijmmtd.2022.020
Subject(s) - medicine , vaccination , asymptomatic , upper respiratory tract infection , respiratory tract infections , pneumonia , immunology , respiratory system
The study was conducted to understand the clinical profile of Covid-19 infections amongst health care workers after vaccination SARS CoV 2 infection was diagnosed with Antigen test / Automated RTPCR in health care workers. All health care workers presenting with symptoms related to Covid-19 atleast 2 weeks after receiving ChAdOx1 nCoV-19 vaccine or high risk primary contacts with asymptomatic infection were included in the study. Detailed clinical profile and other data were collected using a proforma. 82.1 % of the Covid 19 infections after vaccination were defined as Mild Covid-19 and received supportive care at home. Breakthrough infections occurred after a mean duration of 31 days. Since fever and throat pain were the most common presenting symptoms (71.4% and 39.3%), upper respiratory infection was considered as more common. Only 3 patients were defined as Moderate Covid 19 which required hospitalization but did not require oxygen supplementation.Breakthrough infections after ChAdOx1 nCoV-19 vaccination were mild in majority of the cases and most cases presented with upper respiratory tract infection symptoms. The pattern of breakthrough infections helps in determining the efficacy of vaccines and requirement of booster doses of vaccine.