Open AccessAltered structural changes of podocytes, glomerular basement membrane in patients with type 2 diabetes mellitus
Author(s) -
Raghavendra Kenchaiah,
Shantharam
Publication year - 2021
Publication title -
indian journal of clinical anatomy and physiology
Language(s) - English
Resource type - Journals
eISSN - 2394-2126
pISSN - 2394-2118
DOI - 10.18231/j.ijcap.2021.045
Subject(s) - microalbuminuria , albuminuria , glomerular basement membrane , medicine , diabetic nephropathy , diabetes mellitus , type 2 diabetes mellitus , urology , creatinine , endocrinology , renal function , type iv collagen , type 2 diabetes , urinary system , kidney , proteinuria , chemistry , biochemistry , laminin , cell
Diabetic nephropathy is a one of the microvascular complication in patients with type 2 diabetes mellitus due to increased production of free radicals and decreased levels of anti oxidants. The seviority of the disease totally depends on due to damage of foot process of podocytes. Hence, we need to evaluate the altered structural changes of podocytes, glomerular basement membrane in patients with type 2 diabetes mellitus. A total 60 type 2 diabetes mellitus patients were included in the present study and again sub classified into 2 types (Normoalbuminuria 30, Microalbuminuria 30) based on their urinary ACR. Basic laboratory investigations and radio graphical data were collected from the all subjects. A statistical was performed by using SPSS Version 21.0 and P value considers < 0.05 is statistically significant. The significantly elevated levels of plasma FBS, PPBS, Serum Urea, Creatinine, Uric Acid and HbA1c, Urinary albuminuria observed in type 2 diabetes mellitus with microalbuminuria when compared to normoalbuminuria. The radiographical data showed a significantly damaged foot process of podocytes and glomerular basement membrane are observed in patients with microalbuminuria when compared to normoalbuminuria. The increased levels blood sugar and HbA1c, Urinary Albuminuria directly indicates the damage of podocytes and glomerular basement membrane in the kidney. This study suggest continuous monitoring of these parameters may helpful for progression of type 2 diabetes mellitus complications.