Open AccessFuture outlook hydrodynamic drug delivery system of solid oral dosage form: Review
Author(s) -
Akhilesh Kumar Singh,
Neeraj Sharma
Publication year - 2021
Publication title -
ip international journal of comprehensive and advanced pharmacology/ip international journal of comprehensive and advanced pharmacology
Language(s) - English
Resource type - Journals
eISSN - 2581-5555
pISSN - 2456-9542
DOI - 10.18231/j.ijcaap.2021.018
Subject(s) - bioavailability , dosage form , drug delivery , drug , therapeutic window , pharmacology , absorption (acoustics) , medicine , pharmaceutical sciences , chemistry , nanotechnology , materials science , composite material
Over the last few years, therapeutic efficacy of drugs that have poor bioavailability or narrow absorption window have challenged the pharmaceutical industry. In this framework, many Hydrodynamic Balance System (HBS) also known as Gastro retentive dosage forms (GRDFs) have been used to enhance the therapeutic efficacy of drugs. Such drug have a narrow absorption window, are unstable at higher pH, are soluble in acidic conditions, and are local effect in the gastric-part. The drug development with recent technology of various novel polymeric-based gastroretentive drug delivery technologies that may regulate the bioavailability and extend time of therapeutic efficacy of such drugs. Our focus on the significance of in vitro study and in vivo evaluation parameters of various HBS drugs along with their applications. This study provides a promising platform for advantages and guide formulation of HBS dosage form were covered in detail.