Open AccessEffect of intravenous fentanyl versus intravenous fentanyl and paracetamol in attenuating the hemodynamic response to laryngoscopy and endotracheal intubation
Author(s) -
Priyanka Suresh,
Aishwarya Emani
Publication year - 2022
Publication title -
indian journal of clinical anaesthesia
Language(s) - English
Resource type - Journals
eISSN - 2394-4781
pISSN - 2394-4994
DOI - 10.18231/j.ijca.2022.038
Subject(s) - fentanyl , laryngoscopy , anesthesia , medicine , intubation , hemodynamics , tracheal intubation , endotracheal intubation , heart rate , mean arterial pressure , blood pressure
Laryngoscopy and endotracheal intubation are potent stimuli causing increased sympathoadrenal activity. The objective of this study is to assess and compare the effects of intravenous fentanyl versus a combination of intravenous fentanyl and paracetamol in blunting the hemodynamic responses to laryngoscopy and endotracheal intubation. Sixty patients of ASA status I and II, aged 18-60 years of either sex posted for surgeries under general anaesthesia were selected. Patients in group A received intravenous fentanyl 2mcg/kg. Patients in group B received intravenous fentanyl 2mcg/kg and paracetamol 15mg/kg. After intubation vital parameters were recorded at 1, 2, 4 and 6 minute and later once every 10minutes. : After intubation, there was an initial increase in heart rate in both groups. However, this was significantly higher (p=0.004) with group A as compared to group B and remained significantly high for another 6 minutes(p=0.03). There was an increase of mean arterial pressure after intubation in both the groups, however, this was significantly higher in group A and remained significantly high for 6 minutes as compared to group B[p=0.003]. Mean SpO2 was similar in both the groups, and there were no complications during the study. Intravenous fentanyl and paracetamol is more effective in blunting the hemodynamic responses due to laryngoscopy and endotracheal intubation when compared to intravenous fentanyl alone.