Open AccessTrends in oxygen therapy in patients with moderate to severe COVID-19 admitted to the ICU
Author(s) -
Sarika Raghunath,
B Devanand,
Mohammed Nizamuddeen B,
Bala Bhaskar S,
Pradnya Kothari,
Kiran Chand N
Publication year - 2021
Publication title -
indian journal of clinical anaesthesia
Language(s) - English
Resource type - Journals
eISSN - 2394-4781
pISSN - 2394-4994
DOI - 10.18231/j.ijca.2021.098
Subject(s) - medicine , intubation , oxygen therapy , covid-19 , anesthesia , pneumonia , mechanical ventilation , endotracheal intubation , observational study , concomitant , complication , ventilation (architecture) , disease , infectious disease (medical specialty) , mechanical engineering , engineering
The most concerning complication of severe acute respiratory syndrome corona virus 2 (SARSCoV-2) pneumonia is acute hypoxemic failure. Though various antivirals, steroids, immunomodulators have been tried, oxygen therapy remains the mainstay of treatment. After obtaining institutional ethical clearance, a prospective observational study was conducted on 102 COVID-19 positive patients aged 20 years and above, admitted in the ICU with moderate to severe disease. COVID-19 infection was confirmed by polymerase chain reaction or rapid antigen test. Data of two demographically comparable groups i.e., patients on HFNO and NIV was analysed outcome was defined as discharge from ICU, shift to other non-invasive modes of oxygen therapy, endotracheal intubation or death, and comfort level for each mode. The data was analysed using SPSS-16.0, Chi-square test and “t” value test were applied. Comparison ofthe mean number of invasive ventilator free days of HFNO and NIV was insignificant(p>0.05). Among the patients on HFNO (high flow nasal oxygen) 49.09% were stepped down to NRB (non-rebreathing mask) whereas 7.27% went for intubation which is significant compared to NIV mask (non-invasive ventilation), where 13.64% were stepped down to HFNO and 34.09% were intubated (p=0.000). Oxygen therapy with HFNO is associated with better outcome and less mortality when compared with NIV.