Open AccessXanthomatous meningioma, a rare histological variant: Case report
Author(s) -
Sandeep Mohindra,
Ninad Ramesh Patil,
Manjul Tripathi,
Sonikpreet Aulakh,
Nirmalya Banerjee,
Aravind Sekar,
Aman Batish,
Chirag Kamal Ahuja
Publication year - 2021
Publication title -
ip archives of cytology and histopathology research
Language(s) - English
Resource type - Journals
eISSN - 2581-5725
pISSN - 2456-9267
DOI - 10.18231/j.achr.2021.067
Subject(s) - meningioma , pathology , histiocyte , medicine , immunohistochemistry
Xanthomatous meningioma is a WHO grade I metaplastic meningioma where neoplastic cells contain lipid-filled vacuolated cytoplasm. The origin of xanthomatous meningiomas is believed to be from meningothelial cells but diagnosis remains difficult because of their close resemblance with the histiocytes. Peculiar radiographic features may aid in diagnosis, however, definitive diagnosis requires immunohistochemical staining. We report a case of 43-year-old male with sphenoid wing meningioma revealing xanthomatous changes and received treatment as grade 1 meningioma. Though the exact pathophysiology remains unknown, we believe focal or gross metaplastic changes lead to transformation of tumor cells into the xanthomatous subtype. Authors discuss this interesting a rare histologic variant with discussion of the relevant literature.