Open AccessCyclin D1 expression in Peripheral T-Cell Lymphoma: A report of 2 cases
Author(s) -
Shweta P Rathi,
Vinita Pant,
Jay B. Mehta
Publication year - 2021
Publication title -
ip archives of cytology and histopathology research
Language(s) - English
Resource type - Journals
eISSN - 2581-5725
pISSN - 2456-9267
DOI - 10.18231/j.achr.2021.060
Subject(s) - mantle cell lymphoma , cyclin d1 , lymphoma , pathology , cancer research , plasma cell myeloma , hairy cell leukemia , immunohistochemistry , multiple myeloma , cyclin , biology , mantle zone , cell cycle , cell , leukemia , medicine , b cell , bone marrow , immunology , antibody , genetics , germinal center
: Peripheral T-cell lymphomas (PTCLs) represent a heterogeneous group of non-Hodgkin's lymphomas (NHL), characterized by poor outcome, accounting approximately for 10%-15% of all non-Hodgkin lymphomas in the western countries, and with a higher prevalence in Asia. Cyclin D1 immunoreactivity is characteristically seen in mantle cell lymphoma. It is also observed in hairy cell leukemia, plasma cell myeloma and a proportion of diffuse large B-cell lymphomas, however its expression in peripheral T-cell lymphoma is rarely recorded. : We report two cases of peripheral T-cell lymphoma not otherwise specified with heterogeneous nuclear Cyclin D1 immunohistochemical overexpression, due to gene copy gain, a phenomenon similar to that observed in Mantle Cell Lymphoma. : Cyclin D1 expression can be seen in PTCLs, besides mantle cell lymphoma, hairy cell leukemia and plasma cell myeloma and underline the importance of molecular biology integration tests as a diagnostic tool to escape the pitfall.