Open AccessHairy cell leukemia - A case report with recent updates
Author(s) -
Gittwa Vatsaraj Kottangal,
Geeta Vidyadharan
Publication year - 2021
Publication title -
ip archives of cytology and histopathology research
Language(s) - English
Resource type - Journals
eISSN - 2581-5725
pISSN - 2456-9267
DOI - 10.18231/j.achr.2021.029
Subject(s) - pancytopenia , hairy cell leukemia , bone marrow , medicine , leukemia , differential diagnosis , pathology , flow cytometry , biopsy , cytology , hairy cell , bone marrow aspirate , immunology
Hairy cell leukemia (HCL), a rare, chronic B-cell leukemia, first described as a distinct entity in 1958, was recognized as an entity by the World Health Organization in 2008. The disease accounts for 2% of all leukemias and is more frequent in middle-aged to older men. The diagnosis is based on the hairy lymphoid cells in the peripheral smear and the bone marrow aspiration cytology and the bone marrow biopsy showing a monotonous interstitial infiltrate with a fried egg appearance. The classic immunophenotypic profile in the flow cytometry and the V600E mutation confirm the diagnosis. Herein we report a 52- year-old male patient presented with pancytopenia, high-grade fever, and weight loss. The characteristic histomorphological and the flow cytometry features of this leukemia will be used to discuss further the recent updates on the distinct clinicopathologic features, differential diagnosis, treatment, and prognosis of the entity.