Structural oncomarkers in blood plasma in patients with multiple myeloma when using accompanying selective plasma exchange and chemotherapy

The aim of this research work has been to investigate thestructural organization of solid films made from blood plasmataken from patients with secretory multiple myeloma (MM)and identify some specific markers of the tumor process inthem, when conducting selective plasma exchange and medication.Using the methods of wedge- and edge-shaped dehydratation,we have completed morphological screening of solid samplesof blood plasma in 25 patients primarily diagnosed withmultiple myeloma (MM).The obtained results are characterized by profound disordersin the processes of self-organization with predominance ofsome pathological morphotypes of facias having systemic andlocal signs of intoxication and paraproteinemia, which correlatewith their equivalents revealed in the respective biochemicaltests. It has been found that development of multiple myelomais accompanied by formation of some oncomarkers specific tothis sort of oncopathology. The identification of the oncomarkershave been confirmed by the formation of the pathologicalaggregation of anisotropic micro- and macrospherolytes, whichhave demonstrated degenerative transformations upon completionof chemotherapy: they have been shaded because ofproducing complex compounds with chemotherapy drugs ormetabolites of the latter.Conclusion. By this means the cascade of the pathologicalevents have been reflected in our screening morphologicalassays of blood plasma that is of great prognostic value andmay be used in evaluation of efficacy of treatment of multiplemyeloma.