Open AccessInsulin-like growth factors and their binding proteins in the heart in rats in experimental diabetes mellitus, growing Guerin’s carcinoma and under their combination
Author(s) -
Elena Mikhaylovna Frantsiyants,
В. А. Бандовкина,
Irina V. Kaplieva,
Ekaterina I. Surikova,
Natalia D. Cheryarina,
Alla I. Shikhlyarova,
И.В. Нескубина,
Yulia A. Pogorelova,
Lidia K. Trepitaki,
I. A. Goroshinskaya,
И. М. Котиева,
M.I. Morozova
Publication year - 2021
Publication title -
cardiometry
Language(s) - English
DOI - 10.18137/cardiometry.2021.18.138144
Subject(s) - diabetes mellitus , medicine , carcinoma , endocrinology , risk factor , insulin
Diabetes mellitus is an additional risk factor for the development of heart diseases, cardiovascular dysfunction and malignant tumors. The aim of the study was to analyze levels of IGF and IGFBP in heart samples of animals with diabetes mellitus and/ or growing Guerin’s carcinoma. The study included white outbred rats of both genders weighing 180-220 g. The rats of each gender were divided into groups of 8 animals: the intact group; test groups 1 (with diabetes) and 2 (with transplanted Guerin’s carcinoma); the main group (transplanted Guerin’s carcinoma growing in the presence of diabetes mellitus). Levels of IGF-I, IGF-II, IGFBP-1, and IGFBP-2 were measured by ELISA (Mediagnost, Germany) in heart homogenates in animals of all groups