Open AccessApplication of Mathematical Logic for Cytogenetic Definition and Risk Stratification of B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL)
Author(s) -
Gerhard Zugmaier,
Franco Locatelli
Publication year - 2021
Publication title -
medical research archives
Language(s) - English
Resource type - Journals
eISSN - 2375-1924
pISSN - 2375-1916
DOI - 10.18103/mra.v9i2.2328
Subject(s) - syntax , risk stratification , lymphoblastic leukemia , phenotype , identification (biology) , mathematics , leukemia , medicine , computer science , computational biology , biology , artificial intelligence , genetics , immunology , gene , botany
BCP ALL is the most common phenotype of ALL. Identification of recurrent genetic abnormalities specific for BCP-ALL [i.e., t(12;21), t(17;19), t(1;19)], has become an essential tool for confirmation of diagnosis and risk stratification. It can also be used for assessing response to treatment and for detecting the re-emergence of malignant cells. Although the definition of BCP ALL with recurrent genetic abnormalities can be correctly expressed in verbal terms, Mathematical Logic may provide a definition that is more concise. We defined the semantics of conjunctions by the truth values “1” or “0”. In a simplified syntax of English, the conjunctions “and”, “or”, “if and only if” were replaced by the symbols “∧ “, “V”, “↔” respectively. This method permitted definitions stripped from all ambiguous elements.