Open AccessBackgrounds of Computer-Aided Assessment of Morphological Structure in Polymer Drugs-Delivery Microcapsules
Author(s) -
Juliusz L. Kulikowski
Publication year - 2021
Publication title -
medical research archives
Language(s) - English
Resource type - Journals
eISSN - 2375-1924
pISSN - 2375-1916
DOI - 10.18103/mra.v9i2.2312
Subject(s) - computer aided , computer science , quality (philosophy) , quality assessment , biomedical engineering , engineering drawing , drug delivery , medical physics , materials science , nanotechnology , reliability engineering , engineering , evaluation methods , medicine , physics , quantum mechanics , programming language
Microcapsules are widely used as one of the drug delivery means. The paper presents the backgrounds of a method of microcapsules size and shape assessment by computer-aided analysis of microscope images of microcapsules’ cross-sections. The method has been elaborated and is practically used to the microcapsules quality control at the Nalecz Institute of Biocybernetics and Biomedical Engineering PAS in Warsaw. Mathematical definitions of parameters describing the size, shape and inner structure of microcapsules are described in the paper. A general scheme of a computer-aided microcapsules quality assessment procedure is presented. Remarks about the limitations of the applicability of the described microcapsules assessment method are also given. On this basis, directions of future works aimed at improvement of the described microcapsules quality assessment method are suggested.