Open AccessCOVID 19 Severity Correlation between Inflammatory Markers and High Resolution Computerised Tomography
Author(s) -
Ashaq Parrey,
Abir Aijaz,
Mohd Idris Shah Ismail,
Mir Sadaqat,
Manzoor Koka,
Basharat Ahmad,
Hilal Bhat,
Yasmeen Amin
Publication year - 2021
Publication title -
medical research archives
Language(s) - English
Resource type - Journals
eISSN - 2375-1924
pISSN - 2375-1916
DOI - 10.18103/mra.v9i12.2619
Subject(s) - cytokine storm , erythrocyte sedimentation rate , outbreak , chemokine , immune system , immunology , disease , medicine , covid-19 , cytokine , coronavirus , virology , transmission (telecommunications) , inflammation , interleukin 6 , infectious disease (medical specialty) , pathology , electrical engineering , engineering
Coronavirus disease (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus. The outbreak of SARS-CoV-2 was considered to have originally started via a zoonotic transmission associated with the seafood market in Wuhan, China. Later it was recognized that human to human transmission played a major role in the subsequent outbreak. The Inflammatory responses caused by viral replication of SARS-CoV-2 with cellular destruction can recruit macrophages and monocytes and lead to the release of cytokines and chemokines.These inflammatory markers then attract immune cells and activate immune responses, leading to cytokine storms .Many such inflammatory markers have been attributed to determine the severity of SARS-CoV-2 disease and mortality associated with it. The Inflammatory markers such as serum ferritin, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and interleukin-6 (IL-6) have been reported to be significantly associated with the high risks of the development of severe COVID-19 disease.