Open AccessKinomic Alterations in Atypical Meningioma
Author(s) -
Joshua C. Anderson,
Robert B. Taylor,
John B. Fiveash,
Rik de Wijn,
G. Yancey Gillespie,
Christopher D. Willey
Publication year - 2015
Publication title -
medical research archives
Language(s) - Uncategorized
Resource type - Journals
eISSN - 2375-1924
pISSN - 2375-1916
DOI - 10.18103/mra.v0i3.104
Subject(s) - kinome , meningioma , medicine , kinase , cancer research , tyrosine kinase , phenotype , bioinformatics , oncology , computational biology , pathology , biology , receptor , genetics , gene
We sought to profile Atypical Meningioma in a high-throughput manner to better understand the altered signaling within these tumors and specifically the kinases altered in recurrent atypical meningioma. Kinomic Profiles could be used to identify prognostic biomarkers for responders/non-responders to classify future patients that are unlikely to benefit from current therapies. Directly these results could be used to identify drug-actionable kinase targets as well.