Open AccessDrug Analysis Methods
Author(s) -
Victoria V. Shumyantseva,
Tatiana V. Bulko,
Polina I. Koroleva
Publication year - 2019
Publication title -
biomedical chemistry: research and methods
Language(s) - English
Resource type - Journals
ISSN - 2618-7531
DOI - 10.18097/bmcrm00110
Subject(s) - drug , electrode , electrochemistry , materials science , nanotechnology , graphene , ibuprofen , acetaminophen , chemistry , pharmacology , medicine
Modern methods of analysis of drugs for their quantitative assessment are considered. Particular attention is paid to the electrochemical methods of drug registration, based on the reaction of electrooxidation of molecules. Systems and materials for modifying electrodes are described, as well as methods for producing modified electrodes for electrochemical reactions on the surface of electrodes. The authors present data on the electroanalysis of acetaminophen, diclofenac, ibuprofen, omeprazole, using electrodes modified with carbon nanomaterials based on carbon nanotubes and graphene. It was shown that electroanalytical methods allow the registration of therapeutic drugs in a wide range of detectable concentrations (0.1 μМ - 10 mM), which can be used to work with biological fluids (plasma, blood, urine), to conduct drug monitoring and study drug-drug interactions.