Open AccessProtective Effects of the Natural Sesquiterpene Lactones Against Damage Induced by Glutamate and Peroxide in SK-N-MC Cells
Author(s) -
Elena S. Dubrovskaya,
A. V. Semakov,
S. V. Afanasyeva,
Margarita E. Neganova,
V. I. Kozlovski,
С. Г. Клочков
Publication year - 2018
Publication title -
biomedical chemistry: research and methods
Language(s) - English
Resource type - Journals
ISSN - 2618-7531
DOI - 10.18097/bmcrm00051
Subject(s) - sesquiterpene , peroxide , glutamate receptor , chemistry , sesquiterpene lactone , stereochemistry , biology , biochemistry , organic chemistry , receptor
An the present study we evaluated the effect of natural sesquiterpene lactones of plants of the genus Inula on the cells of neuroblastoma SK-N-MC under conditions of toxic stress induced by H2O2 and glutamate. Lactones increased cell survival under these conditions and the leader compounds were identified in this series. A putative mechanism for the protective action of lactones on cells under condition toxic stress has been proposed.