Protective Effects of the Natural Sesquiterpene Lactones Against Damage Induced by Glutamate and Peroxide in SK-N-MC Cells | Zendy

Elena S. Dubrovskaya | Zendy; А. В. Семаков | Zendy; S. V. Afanasyeva | Zendy; Маргарита Е. Неганова | Zendy; V. I. Kozlovski | Zendy; С. Г. Клочков | Zendy

Open Access

Protective Effects of the Natural Sesquiterpene Lactones Against Damage Induced by Glutamate and Peroxide in SK-N-MC Cells

Author(s) -

Elena S. Dubrovskaya,

А. В. Семаков,

S. V. Afanasyeva,

Маргарита Е. Неганова,

V. I. Kozlovski,

С. Г. Клочков

Publication year - 2018

Publication title -

biomedical chemistry research and methods

Language(s) - English

Resource type - Journals

ISSN - 2618-7531

DOI - 10.18097/bmcrm00051

Subject(s) - sesquiterpene , peroxide , glutamate receptor , chemistry , sesquiterpene lactone , stereochemistry , biology , biochemistry , organic chemistry , receptor

An the present study we evaluated the effect of natural sesquiterpene lactones of plants of the genus Inula on the cells of neuroblastoma SK-N-MC under conditions of toxic stress induced by H2O2 and glutamate. Lactones increased cell survival under these conditions and the leader compounds were identified in this series. A putative mechanism for the protective action of lactones on cells under condition toxic stress has been proposed.

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