Open AccessCarbamoylimines of Methyltrifluoropyruvate in the Diels-Alder’s Azareaction with Cyclopentadiene
Author(s) -
A. Yu. Aksinenko,
И. П. Калашникова,
В. Б. Соколов
Publication year - 2018
Publication title -
biomedical chemistry: research and methods
Language(s) - English
Resource type - Journals
ISSN - 2618-7531
DOI - 10.18097/bmcrm00016
Subject(s) - cyclopentadiene , trifluoromethyl , dept , chemistry , diels–alder reaction , fluorine 19 nmr , stereochemistry , organic chemistry , nuclear magnetic resonance spectroscopy , alkyl , catalysis
Carbamoylimines of methyl trifluoropyruvate react with cyclopentadiene with to formation of trifluoromethyl-containing azabicyclo [2.2.1] heptenes and tetrahydrocyclopenta[e][1,3]oxazines. NMR experiments involving DEPT and 1H{19F} determined the structure of the synthesized heterocycles and assignment of the signals in NMR spectra and established the exo-position of the CF3-group in azabicyclo[2.2.1]heptenes.