Open AccessPractical recommendations for choosing an immunobiological preparation for the treatment of severe bronchial asthma of T2-endotype
Author(s) -
Natalia Nenasheva,
О М Курбачева,
С. Н. Авдеев,
С. В. Федосенко,
А. В. Емельянов,
А. С. Белевский,
N I Ilina,
Н. П. Княжеская,
С. К. Зырянов,
Г. Л. Игнатова,
И. В. Демко,
Л. В. Шульженко,
И. В. Лещенко,
Р. С. Фассахов,
Б. А. Черняк,
Н. Г. Недашковская,
Ele. Bobrikova,
Д. В. Демина
Publication year - 2020
Publication title -
pulʹmonologiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 6
eISSN - 2541-9617
pISSN - 0869-0189
DOI - 10.18093/0869-0189-2020-30-2-227-244
Subject(s) - mepolizumab , omalizumab , benralizumab , endotype , medicine , dupilumab , asthma , immunology , immunoglobulin e , monoclonal antibody , allergy , antibody , interleukin 5 , disease , eosinophil , interleukin , cytokine
Biological therapy of bronchial asthma (BA) is a modern method of treating severe forms of the disease, that are uncontrolled by traditional pharmacotherapeutic approaches. Currently, 5 monoclonal antibody (AT) preparations are registered in the world for the treatment of severe bronchial asthma (SBA) of the T2 endotype (T2-SBA) – antibodies, binding to immunoglobulin (Ig) E (anti-IgE – omalizumab), interleukin antagonists (IL)-5 (anti-IL-5 – mepolizumab, resizumab) and its receptor (anti-IL-5Rα – benralizumab), as well as antibodies, that selectively bind to the IL-4 and -13 receptor (anti-IL-4 /13Rα – dupilumab). The article presents data on the effectiveness of these drugs in relation to the key characteristics of SBA, formulates clinical and laboratory criteria, the study of which in real practice can potentially predict the likelihood of a clinical response to a particular type of biological therapy. An algorithm is proposed for choosing a targeted therapy strategy for patients with SBA, clinically associated with allergies, for patients with severe non-allergic eosinophilic BA and for patients with eosinophilic BA of a combined phenotype.