Open AccessParticle pollution as a risk factor for lung carcinoma
Author(s) -
А. Ф. Колпакова,
Ruslan N. Sharipov,
Oxana A. Volkova,
Fedor Kolpakov
Publication year - 2019
Publication title -
pulʹmonologiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 6
eISSN - 2541-9617
pISSN - 0869-0189
DOI - 10.18093/0869-0189-2019-29-4-477-485
Subject(s) - lung cancer , lung , medicine , risk factor , carcinoma , epidemiology , pathogenesis , oncology , pathology , environmental health
Current view on a relationship between particle pollution, morbidity and mortality of lung carcinoma were discussed in the article. Published epidemiological, clinical and laboratory studies suggest particle pollution, especially metal containing particulate matter (PM), to be a risk factor for lung carcinoma occurrence. PM-associated injury of epithelial cell genome and epigenetic lesions are an important part of pathogenesis of lung carcinoma. Systemic research findings and formalized reports could improve our knowledge on lung cancer pathogenesis and could be used in clinical practice for risk assessment, early detection and prognosis of lung cancer and improvement in treatment efficacy.