Open AccessOsteoporosis in cystic fibrosis: terminology, diagnosis and clinical signs
Author(s) -
И. А. Баранова,
E.I. Kondratyeva,
С. А. Красовский
Publication year - 2017
Publication title -
pulʹmonologiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 6
eISSN - 2541-9617
pISSN - 0869-0189
DOI - 10.18093/0869-0189-2017-27-2-291-297
Subject(s) - medicine , osteoporosis , cystic fibrosis , disease , vitamin d and neurology , vitamin d deficiency , intensive care medicine , pediatrics
Continuous growth of proportion of adult patients in the total number of patients with cystic fibrosis (CF) is accompanied by the increasing rate of pulmonary and extrapulmonary complications, mainly secondary osteoporosis. This is a multifactorial disease predominantly associated with chronic microbial and inflammatory processes, vitamin D deficiency, low body mass index, delayed puberty and hypogonadism, and long-term (≥3 months) therapy with oral steroids. Controversal issues of terminology and current diagnostic approach to osteoporosis in CF patients have been discussed in the article. Diagnosis of osteoporosis in CF patients should not be based solely on osteodensitometry findings but also on thorough analysis of clinical signs and symptoms, other image diagnostic investigations and laboratory data. Detection of the risk factors could help to control this disease.