Open Access2016 Influenza epidemics: clinical and epidemiological features and current abilities for effective treatment (according to data from the Clinical Infectious Diseases Hospital No. 1, Moscow)
Author(s) -
Л. В. Колобухина,
Elena Burtseva,
Irina Kruzhkova,
Л Н Меркулова,
Р В Вартанян,
Л. Б. Кистенева,
Е. С. Кириллова,
С. В. Трушакова,
А. Г. Росаткевич,
К. Г. Краснослободцев,
Е. А. Мукашева,
П. В. Бойцов,
Е. И. Келли,
О. Е. Амброси,
Т. В. Арсеньева,
М. В. Базарова,
А. В. Девяткин,
О. А. Суточникова
Publication year - 2016
Publication title -
pulʹmonologiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 6
eISSN - 2541-9617
pISSN - 0869-0189
DOI - 10.18093/0869-0189-2016-26-4-444-452
Subject(s) - medicine , epidemiology , pneumonia , urinalysis , virus , pediatrics , influenza a virus , pandemic , virology , infectious disease (medical specialty) , covid-19 , urine , disease
The aim of this study was to monitor in-hospital influenza virus infection during 2015 – 2016 epidemic flu season. Methods. Influenza virus was searched in patients hospitalized to a clinical infectious diseases hospital with acute respiratory viral infection during 2015 – 2016 influenza seasonal growth period using real-time RT-PCR method. Influenza virus was isolated from nasal swabs and autopsy material using canine kidney cell line. Other laboratory methods used included complete blood count, blood chemistry, blood gas analysis, urinalysis, and chest X-ray examination. Results. We examined 1,491 patients (375 adults, 546 children, 570 pregnant women with early gestational age). The proportion of hospitalized patients with confirmed A / H1N1pdm09 influenza in January – February, 2016, was 91.3%. A / H3N2 influenza virus was diagnosed in 5.7%, influenza B virus was isolated in 1.2% of patients. Totally, influenza virus was detected in 35.2% of samples, of which 30.1% of samples were obtained from adults, 33.7% of samples were obtained from children, and 39.8% of samples were obtained from pregnant women. The prevalent patient’s age was 15 to 60 years (76.1%) in adults and 3 to 6 years in children. Moderate course of influenza with a high rate of hospital admission was seen more often and was similar to that of 2009 – 2010 epidemic season. Proportion of patients with flu complicated by pneumonia was higher than that in 2014 – 2015 epidemic season. Bilateral lung injury was diagnosed in 48.4% of patients. High mortality in ICU (46.4%) was due to delayed start of antiviral treatment and late admission to a hospital. Conclusion. In 2015 – 2016 epidemic flu season, higher morbidity, complications and poor outcomes were related to predominant infection of A – H1N1pdm09 influenza virus. Risk factors of complications and death were delayed care seeking, lack of modern antiviral medications and comorbidity.