Open AccessVascular reactivity in patients with bronchial asthma
Author(s) -
Т.В. Смирнова,
Juliy M. Perelman,
Victor P. Кolosov
Publication year - 2008
Publication title -
pulʹmonologiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 6
eISSN - 2541-9617
pISSN - 0869-0189
DOI - 10.18093/0869-0189-2008-0-6-63-66
Subject(s) - brachial artery , medicine , airway , cardiology , endothelium , asthma , reactive hyperemia , pulmonary artery , hemodynamics , vascular resistance , anesthesia , blood flow , blood pressure
Ultrasound investigation was done in 96 patients with bronchial asthma to define changes in endothelium-dependent and endothelium-independent reactivity of brachial artery and their relations to central and pulmonary hemodynamics as well as to the airway reactivity. Tests with reactive hyperemia and nitroglycerine revealed disorders of vascular reactivity (decrease in endothelium-dependent and endothelium-independent brachial artery dilation) which progressively worsened while severity of the disease increased. Dilation disorders in the systemic circulation closely related to the left ventricle diastolic dysfunction, increased total pulmonary vascular resistance and the airway reactivity.