Open AccessPathomorphology of bronchopulmonary diseases in workers exposed to colored metal aerosols
Author(s) -
Н С Соркина,
Л.П. Кузьмина,
L A Dueva,
Т. Б. Бурмистрова,
T. Yu. Stasenkova,
V. A. Stesikova,
O. I. Rumyantseva,
С.Г. Комарова,
L. V. Khabusova,
Л. М. Безрукавникова
Publication year - 2008
Publication title -
pulʹmonologiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 6
eISSN - 2541-9617
pISSN - 0869-0189
DOI - 10.18093/0869-0189-2008-0-4-81-85
Subject(s) - medicine , colored , heavy metals , immunology , pathology , chemistry , environmental chemistry , materials science , composite material
Etiopathogenic features and diagnostic criteria of occupational diseases studying in workers engaged in colored metallurgy have been given in the paper. Polyvalent sensitization to metal allergens (nickel, chrome, beryllium, manganese) was found. A toxic effect of nickel on DNA was shown that could be used as a biomarker of exposure for biological monitoring in colored metallurgy workers. Biochemical investigations determined the main pathogenic mechanisms underlying pathomorphology of bronchopulmonary diseases caused by the exposure of colored metals, such as activation of lipid peroxidation, "proteolysis – antiproteolysis" imbalance, growing significance of infection. This is the first study demonstrating clinical and biochemical parallels between characteristics of development and course of respiratory pathology caused by the exposure of colored metals. Infectious, inflammatory, toxico-allergic, and destructive processes predominated in this pathology. Preventive and rehabilitation strategies have been developed.