Open AccessApplication of functional tests to estimate arterial stiffness in asthmatic patients
Author(s) -
Б. И. Гельцер,
T. A. Brodskaya,
В. А. Невзорова
Publication year - 2008
Publication title -
pulʹmonologiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 6
eISSN - 2541-9617
pISSN - 0869-0189
DOI - 10.18093/0869-0189-2008-0-2-42-46
Subject(s) - medicine , asthma , arterial stiffness , cardiology , pulse wave velocity , exacerbation , aorta , pathological , blood pressure
The purpose of the research was to study mechanical properties of the aorta using functional tests in patients with asthma. We examined 54 asthmatic patients and 25 healthy volunteers using noninvasive arteriography (arteriograph TensioClinic TL1, TensioMed, Hungary), exercise (PE) and nitroglycerine (NG) tests. Transitory increase in aortal stiffness was observed in patients with exacerbation of severe and moderate asthma. The degree of this increase closely correlated to severity of the disease, ventilation disorders, and hypoxemia. These results suggest higher cardiovascular risk in such patients. Patients with asthma demonstrated amplified or weakened reaction of aortic pulse wave velocity (aPWV) to the PE depending on baseline values of these parameters: higher aPWV corresponded to weaker reaction to PE, and vise versa. As a whole, reduction in arterial stiffness during the NG test in asthma patients was significantly less than in healthy persons. The aPWV reaction to NG was more prominent during exacerbations of severe asthma. Therefore, functional tests investigating mechanical properties of aorta substantially supplemented traditional arteriography. Pathological reaction to PE was seen in some patients with stable asthma and normal aPWV values.