Open AccessInflammatory marker levels and peripheral blood circulation in skin microvessels in patients with chronic obstructive pulmonary disease
Author(s) -
Irina V. Tikhonova,
Arina V. Tankanag,
Ninel I. Kosyakova,
Н. К. Чемерис
Publication year - 2008
Publication title -
pulʹmonologiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 6
eISSN - 2541-9617
pISSN - 0869-0189
DOI - 10.18093/0869-0189-2008-0-1-57-61
Subject(s) - proinflammatory cytokine , exacerbation , medicine , microcirculation , vasodilation , copd , cytokine , peripheral , perfusion , respiratory system , blood flow , cardiology , inflammation , immunology , pathology
Levels of inflammatory markers and skin microcirculation were studied in patients with chronic obstructive pulmonary disease. Proinflammatory cytokine concentrations and number of desquamated endothelial cells in blood flow were significant increased during exacerbation compared with controls. The increase in proinflammatory cytokine concentrations in exacerbation was accompanied by increased skin perfusion, increased oscil lation amplitudes in the frequency ranges of respiratory rhythm and higher endothelial activity compared with controls. In stable condition, the lev els of proinflammatory cytokines decreased compared with those in exacerbation. Myogenic activity was decreased twice in patients with stable con dition compared with healthy persons. The endothelialdependent vasodilation did not change and the endothelialindependent vasodilation increased in all patients compared with controls.