Open AccessAbout the possible role of endogenous modulators of β-adrenoreactivity and M-cholinoreactivity in the pathogenesis of asthma
Author(s) -
В. И. Циркин,
Т. Н. Кононова,
Е. Н. Сизова,
Irina Popova,
A. S. Vakhrusheva
Publication year - 2007
Publication title -
pulʹmonologiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 6
eISSN - 2541-9617
pISSN - 0869-0189
DOI - 10.18093/0869-0189-2007-0-5-46-50
Subject(s) - endogeny , asthma , pathogenesis , medicine , endocrinology , blocking (statistics) , blockade , receptor , statistics , mathematics
Ability of blood sera from 19 asthmatic children and 56 asthmatic adults to modify reactivity of β-adrenoreceptors and M-cholinoreceptors in isolated smooth muscles of the uterus horns from nonpregnant rats (n = 234) and cow trachea (n = 36) have shown that asthma presence did not change serum myocyte-stimulating activity but reduced the sensitizing activity of β-adrenoreceptors and the blocking activity of M-cholinoreceptors and enhanced the blocking activity of β-adrenoreceptors. The similar changes were also seen in child urine and indicated the decreased level of the endogenous sensitizer of β-adrenoreceptors and the growing level of the endogenous blocker of β-adrenoreceptors in asthma patients and the decreased level of endogenous blocker of M-cholinoreceptors in certain asthmatics. These events could provide asthma occurrence.