Open AccessA role of respiratory infections in exacerbations of asthma
Author(s) -
Alexander Chuchalin,
Т. П. Оспельникова,
Г. Л. Осипова,
N. V. Lizogub,
Valentina Gervazieva,
Vera Krivitskaya,
S. S. Grigoryan,
С А Мазурина,
Е. Б. Файзулоев,
Alexandra Nikonova,
В. Н. Панкратова,
С. А. Гончарова
Publication year - 2007
Publication title -
pulʹmonologiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 6
eISSN - 2541-9617
pISSN - 0869-0189
DOI - 10.18093/0869-0189-2007-0-5-14-18
Subject(s) - mycoplasma pneumoniae , chlamydophila pneumoniae , virology , interferon , immunology , asthma , respiratory system , medicine , virus , mycoplasma , chlamydophila , chlamydia , biology , microbiology and biotechnology , pneumonia , chlamydiaceae
Nineteen patients aged 18–65 years with moderate and severe exacerbations of atopic asthma were examined for respiratory viruses, Mycoplasma pneumoniae, and Chlamydophila pneumoniae. Interferon system, IL-4 and γ-IFN serum levels were also investigated. Viral infections (RS-virus, adenovirus, influenza types A (H1N1, H3N2) and B viruses, parainfluenza types 1 and 3 viruses) were diagnosed serologically or using PCR with direct detection of viral nucleic acids in 73.6 % of the patients. Diagnostic level of Mycoplasma pneumoniae antigen was found in 78.9 % of the patients, anti-Chlamydophila pneumoniae antibodies were detected in 31.6 %. Leukocyte interferon-producing function was decreased in all the patients.