Open AccessMolecular and genetic mechanisms of eosinophil apoptosis in childhood asthma
Author(s) -
И. А. Деев,
А. Э. Сазонов,
Л. М. Огородова
Publication year - 2007
Publication title -
pulʹmonologiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 6
eISSN - 2541-9617
pISSN - 0869-0189
DOI - 10.18093/0869-0189-2007-0-4-17-22
Subject(s) - asthma , effector , eosinophil , apoptosis , peripheral blood , immunology , messenger rna , medicine , gene expression , interleukin 4 , gene , biology , immune system , genetics
Expression of mRNA apoptosis effectors, antagonists (bcl-2), prodeath protein (bax) and matrix activity of IL-5 in peripheral blood eosinophils were evaluated in children with asthma before and after therapy. Expression of bcl-2 was not revealed in peripheral blood eosinophils of healthy children, however increased expression of IL-5 gene mRNA and increased bcl-2 activity were found in children with asthma. After the course of basis therapy in asthma children, activity of antiapoptotic effectors of bcl-2 family decreased and mRNA expression of proapoptotic factors increased. These modifications were associated with improvement in asthma symptoms and functional parameters.