Open AccessInsulin-resistance and its causes in bronchial asthma patients
Author(s) -
Irina Liverko,
A M Ubaĭdullaev
Publication year - 2005
Publication title -
pulʹmonologiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 6
eISSN - 2541-9617
pISSN - 0869-0189
DOI - 10.18093/0869-0189-2005-0-1-62-65
Subject(s) - insulin resistance , insulin , asthma , hypoxia (environmental) , medicine , receptor , endocrinology , insulin receptor , chemistry , oxygen , organic chemistry
We investigated 75 bronchial asthma (BA) patients to determine the incidence and causes of insulin resistance occurrence. We performed a subcutaneous insulin test, assessed tissue hypoxia and studied the oxygen transferring blood system. The impairment of insulin binding with the receptors was found in the BA patients due to both decreasing in the receptors affinity to insulin and reduction in their number under the tissue hypoxia, pH shift and the acid-base imbalance provided by the therapy with steroids and adrenoceptor agonists. This results in insulin resistance. The insulin resistance was detected in 58.7 % of the BA patients in our study.