Open AccessAssociation of polyunsaturated fatty acids treatment with coronary mortality. A meta-analysis
Author(s) -
С Л Плавинский,
А. Н. Баринова,
K. D. Danishevski
Publication year - 2019
Publication title -
kardiologiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.159
H-Index - 16
eISSN - 2412-5660
pISSN - 0022-9040
DOI - 10.18087/cardio.n680
Subject(s) - polyunsaturated fatty acid , docosahexaenoic acid , eicosapentaenoic acid , confidence interval , medicine , meta analysis , subgroup analysis , gastroenterology , fatty acid , biology , biochemistry
Aim. A meta-analysis was undertaken to sum up data on long-chain polyunsaturated fatty acids treatment and coronary deaths. Methods. Only studies with no less than 500 participants and length of follow-up no less than one year were included. Total number of studies was 13 with 127455 participants. Results. Fixed factor (Peto) model demonstrated significant decrease in cardiac deaths in polyunsaturated fatty acids -treated group. (OR=0,89, 95%CI: 0,83-0,95, р=0,001). Random factor model confidence interval also does not included one (OR=0,88, 95%CI: 0,80-0,97, p=0.008). Subgroup analysis of studies that used therapy with 460 mg eicosapentaenoic acid and 380 docosahexaenoic acid per day demonstrated significant reduction in cardiac deaths (OR=0,84, 95%CI: 0,77-0,92) in both fixed factor and random factor models. Conclusion. Correspondingly supplementation with polyunsaturated fatty acids associated with lower coronary mortality.