Open AccessEvaluation of endothelial dysfunction and the possibility of its correction at the present stage in patients with cardiovascular diseases
Author(s) -
M O Samolyuk,
N. Yu. Grigorieva
Publication year - 2019
Publication title -
kardiologiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.159
H-Index - 16
eISSN - 2412-5660
pISSN - 0022-9040
DOI - 10.18087/cardio.2524
Subject(s) - endothelial dysfunction , life expectancy , intensive care medicine , medicine , endothelium , nitric oxide , stage (stratigraphy) , clinical practice , quality of life (healthcare) , cardiology , risk analysis (engineering) , physical therapy , biology , environmental health , paleontology , population , nursing
The review describes the current understanding of endothelial dysfunction, methods of its evaluation, and highlights the advantages and disadvantages of various techniques. The role of nitric oxide and endothelin as important markers of endothelial dysfunction is shown, and the methods of their determination in clinical practice are described. The authors conclude that in order to improve the life expectancy and quality of life of patients with cardiovascular diseases, reduce the risk and frequency of complications and mortality rates, it is necessary to study the function of endothelium in more detail and to look for ways of drug correction, taking into account the pathogenetic mechanisms of its formation.