Open AccessStatin-associated muscle symptoms: epidemiology, risk factors, mechanisms and treatment
Author(s) -
A. I. Dyadyk,
Т. Е. Куглер,
S. R. Zborowskyy,
Yu. V. Suliman
Publication year - 2019
Publication title -
kardiologiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.159
H-Index - 16
eISSN - 2412-5660
pISSN - 0022-9040
DOI - 10.18087/cardio.2522
Subject(s) - statin , medicine , epidemiology , adverse effect , intensive care medicine , drug , residual risk , hydroxymethylglutaryl coa reductase inhibitors , pharmacotherapy , physical therapy , pharmacology
Statins are widely prescribed and the risk of adverse drug reactions of lipid-lowering therapy is actively discussed, including muscle symptoms. This review synthesizes the knowledge about the clinical aspects of statin-associated muscle symptoms, which is important for the practitioner. Potential mechanisms of their development, risk factors, clinical manifestations, treatment and prevention are described. Timely detection the side effects of statins makes it possible to diagnose and eliminate, which is crucial for conducting lipid-lowering therapy for patients with atherosclerotic cardiovascular diseases. Management of statin-associated muscle symptoms requires altering (reduced dosages, use of another statin or alternative lipid-lowering drugs) or discontinuing the statin treatment.