Open AccessE-Selectin as a Marker of Endothelial Dysfunction in Patients with Coronary Artery Disease Including Those with Type 2 Diabetes Mellitus
Author(s) -
A. V. Zhito,
A. O. Yusupova,
Maria Kozhevnikova,
Anastasia Shchendrygina,
Е. А. Привалова,
Yu. N. Belenkov
Publication year - 2020
Publication title -
kardiologiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.159
H-Index - 16
eISSN - 2412-5660
pISSN - 0022-9040
DOI - 10.18087/cardio.2020.4.n1066
Subject(s) - medicine , type 2 diabetes mellitus , endothelial dysfunction , diabetes mellitus , cardiology , coronary artery disease , type 2 diabetes , disease , plethysmograph , venous blood , gastroenterology , endocrinology
Aim To determine concentration of the endothelial dysfunction (ED) marker, serum E-selectine, in patients with ischemic heart disease (IHD) in combination with type 2 diabetes mellitus (DM) and without DM. Material and methods The study included 60 IHD patients; 31 of them also had type 2 DM. E-selectin was measured in blood of all patients. In addition, a comprehensive evaluation of the morpho-functional condition of large blood vessels and microvasculature (MV) was performed by laser finger plethysmography (LFP) and nailfold computed videocapillaroscopy (CVC). Results Concentration of E-selectin was increased in IHD patients with type 2 DM (35.2 [29.0; 47.35] ng / ml vs. 31.7 [20.85; 36.68] ng / ml for IHD patients; p=0.028). A significant (p=0.018 and 0.016, respectively) decrease in the phase shift was observed in IHD patients with type 2 DM ( – 4.4 [ – 8.7; – 2.45] ms) compared to IHD patients ( – 1.9 [ – 3.95; – 0.38] ms). The capillary density evaluated in the venous occlusion test was reduced in IHD patients with type 2 DM (67.70 [57.83; 80.69]) compared to IHD patients (80.80 [69.05; 99.08]). Conclusion The signs of ED observed in patients of both groups were more pronounced in IHD patients with type 2 DM.