Open AccessFocus on the Myocardial Hypertrophy from the Perspective of Transcriptomics and Metabolomics
Author(s) -
G. A. Shakaryants,
M. V. Kozhevnikova,
V. Yu. Kaplunova,
Е. А. Привалова,
А. С. Лишута,
E O Korobkova,
Yu. N. Belenkov
Publication year - 2020
Publication title -
kardiologiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.159
H-Index - 16
eISSN - 2412-5660
pISSN - 0022-9040
DOI - 10.18087/cardio.2020.4.n1063
Subject(s) - myocardial hypertrophy , metabolomics , transcriptome , omics , medicine , computational biology , cardiac hypertrophy , bioinformatics , muscle hypertrophy , profiling (computer programming) , microrna , computer science , biology , gene expression , genetics , gene , operating system
This review presents major directions in studies of myocardial hypertrophy from the aspect of transcriptomics and metabolomics. Understanding of trigger mechanisms of myocardial hypertrophy will permit transition from basic studies to individualized clinical application of innovative technologies in the treatment of heart diseases, such as targeted therapy. At the present time, methods have been developed for diagnostics and prediction of cardiovascular diseases based on the metabolomic profiling and the evaluation of microRNA expression. Progress in studying molecular and genetic processes underlying the development of cardiovascular diseases may provide invaluable information for clinical cardiology.