Open AccessSystematic Analysis of the Roles of Trace Elements in the Prevention and Treatment of Chronic Heart Failure
Author(s) -
О. А. Громова,
I. Yu. Torshin,
Ж. Д. Кобалава,
A G Nazarenko
Publication year - 2019
Publication title -
kardiologiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.159
H-Index - 16
eISSN - 2412-5660
pISSN - 0022-9040
DOI - 10.18087/cardio.2019.6.n683
Subject(s) - heart failure , magnesium , medicine , selenium , magnesium deficiency (plants) , cardiology , anemia , vascular tone , hypomagnesemia , chemistry , nitric oxide , organic chemistry
Systematic analysis of 3 728 publications on the relationship between microelement status and chronic heart failure (CHF) was carried out. Three main areas of research have been identified: 1) magnesium, electrolytes and CHF; 2) the transcriptional and antioxidant effects of zinc, selenium, copper; 3) iron-deficiency anemia and CHF. In this paper, we consider a complex of relationships between the magnesium insufficiency and CHF, the effect of magnesium on vascular tone, mitochondria, heart rhythm and the susceptibility of cardiomyocytes to adrenergic stimulation. Using magnesium orotate for the treatment of CHF is a feasible approach to compensate magnesium insufficiency in patients with CHF.