Open AccessInvestigating the Effect of Carbon Nanomaterials Reinforcing Poly(ε-Caprolactone) Printed Scaffolds for Bone Repair Applications
Author(s) -
Yanhao Hou,
Weiguang Wang,
Paulo Bártolo
Publication year - 2020
Publication title -
international journal of bioprinting
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.014
H-Index - 24
eISSN - 2424-7723
pISSN - 2424-8002
DOI - 10.18063/ijb.v6i2.266
Subject(s) - biocompatibility , caprolactone , biocompatible material , materials science , scaffold , biodegradation , graphene , nanomaterials , tissue engineering , 3d printed , polymer , nanotechnology , composite material , biomedical engineering , chemistry , copolymer , medicine , organic chemistry , metallurgy
Scaffolds, three-dimensional (3D) substrates providing appropriate mechanical support and biological environments for new tissue formation, are the most common approaches in tissue engineering. To improve scaffold properties such as mechanical properties, surface characteristics, biocompatibility and biodegradability, different types of fillers have been used reinforcing biocompatible and biodegradable polymers. This paper investigates and compares the mechanical and biological behaviors of 3D printed poly(ε-caprolactone) scaffolds reinforced with graphene (G) and graphene oxide (GO) at different concentrations. Results show that contrary to G which improves mechanical properties and enhances cell attachment and proliferation, GO seems to show some cytotoxicity, particular at high contents.