Open AccessGraphene Oxide Induces Ester Bonds Hydrolysis of Poly-l-lactic Acid Scaffold to Accelerate Degradation
Author(s) -
Cijun Shuai,
Li Yang,
Wenjing Yang,
Li Yu,
Shuping Peng,
Pei Feng
Publication year - 2020
Publication title -
international journal of bioprinting
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.014
H-Index - 24
eISSN - 2424-7723
pISSN - 2424-8002
DOI - 10.18063/ijb.v6i1.249
Subject(s) - ultimate tensile strength , degradation (telecommunications) , scaffold , hydrogen bond , materials science , oxide , biocompatibility , graphene , chemical engineering , hydrolysis , lactic acid , molecule , composite material , chemistry , organic chemistry , nanotechnology , biomedical engineering , medicine , telecommunications , engineering , biology , computer science , bacteria , metallurgy , genetics
Poly-l-lactic acid (PLLA) possesses good biocompatibility and bioabsorbability as scaffold material, while slow degradation rate limits its application in bone tissue engineering. In this study, graphene oxide (GO) was introduced into the PLLA scaffold prepared by selective laser sintering to accelerate degradation. The reason was that GO with a large number of oxygen-containing functional groups attracted water molecules and transported them into scaffold through the interface microchannels formed between lamellar GO and PLLA matrix. More importantly, hydrogen bonding interaction between the functional groups of GO and the ester bonds of PLLA induced the ester bonds to deflect toward the interfaces, making water molecules attack the ester bonds and thereby breaking the molecular chain of PLLA to accelerate degradation. As a result, some micropores appeared on the surface of the PLLA scaffold, and mass loss was increased from 0.81% to 4.22% after immersing for 4 weeks when 0.9% GO was introduced. Besides, the tensile strength and compressive strength of the scaffolds increased by 24.3% and 137.4%, respectively, due to the reinforced effect of GO. In addition, the scaffold also demonstrated good bioactivity and cytocompatibility.