Open AccessComparative analysis of long-term results of external beam and combined radiotherapy in high-risk prostate cancer patients
Author(s) -
A.V. Potapova Potapova,
И. А. Гладилина,
А. В. Петровский,
Л Е Ротобельская,
M Shabanov,
В. А. Черняев,
В. Н. Шолохов,
С. И. Ткачев
Publication year - 2021
Publication title -
zlokačestvennye opuholi
Language(s) - English
Resource type - Journals
eISSN - 2587-6813
pISSN - 2224-5057
DOI - 10.18027/2224-5057-2020-10-3-26-33
Subject(s) - prostate cancer , medicine , radiation therapy , external beam radiotherapy , urology , androgen deprivation therapy , prostatectomy , external beam radiation , prostate , oncology , cancer
Prostate cancer (PCa) of high risk is one of the crucial problems in urological oncology. Radiation therapy (RT), along with radical prostatectomy, is an important component of the complex treatment of patients with high‑risk PCa. To improve the long‑term oncological results of RT dose escalation is advocated. Currently, dose escalation can be reached via external beam irradiation and interstitial RT techniques. The study included 109 patients with high‑risk PCa who underwent either external beam RT up to 76 Gy, or combined RT (external beam + interstitial RT) using 125 I sources with long‑term androgen deprivation therapy. Comparative analysis of long‑term results of patients with high‑risk PCa treatment showed an improvement in 5‑year disease‑free survival rates after combined RT compared with external beam RT. Acute rectal toxicity was decreased in combined RT group compared to patients after external beam RT: 13.2 % and 46.4 %, respectively (p < 0.01).