Open AccessEXPERIENCE OF APPLICATION OF ANTI PD-1 THERAPY IN MMR-DEFICIENCY ENDOMETRIAL CANCER
Author(s) -
Карине Г. Чам,
Григорий Александрович Раскин,
Т. Андабеков,
М. К. Родина,
И. О. Руткин,
Дмитрий М. Кондрачук,
V L Vinokurov
Publication year - 2018
Publication title -
zlokačestvennye opuholi
Language(s) - English
Resource type - Journals
eISSN - 2587-6813
pISSN - 2224-5057
DOI - 10.18027/2224-5057-2018-8-2-60-63
Subject(s) - endometrial cancer , medicine , dna mismatch repair , oncology , microsatellite instability , immunotherapy , uterus , cancer , lynch syndrome , biology , gene , colorectal cancer , microsatellite , biochemistry , allele
Currently, more and more studies show the effectiveness of anti-PD-1 therapy in tumors with a deficiency of the unpaired DNA nucleotide repair system (MMR). According to various sources in endometrial cancer, the MMR deficit is determined in 20–30 % of cases. This paper presents the experience of successful immunotherapy (anti PD-1) in a patient with metastatic endometrioid adenocarcinoma of the uterus with a deficiency of MMR.