Open AccessROLE OF SUBSTANCE P IN PANCREATITIS AND ASSOCIATED DISEASES
Author(s) -
Vaishnavi Sundar,
Shalini Ramasamy,
Sanjana Vimal,
Anupam Dutta,
Kshitija Joshi,
Venkatraman Manickam,
Ramasamy Tamizhselvi
Publication year - 2021
Publication title -
journal of experimental biology and agricultural sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.108
H-Index - 2
ISSN - 2320-8694
DOI - 10.18006/2021.9(5).580.590
Subject(s) - substance p , neurogenic inflammation , neuropeptide , pancreatitis , acute pancreatitis , inflammation , pathophysiology , medicine , neuroscience , pancreatic cancer , receptor , bioinformatics , pharmacology , biology , cancer
Substance P (SP) is a neuropeptide that has its place in the tachykinin family and helps in the transmission of neurogenic signals. SP is also a neuromodulator that plays a crucial part in pain during inflammatory processes. It is produced by the capsaicin-sensitive unmyelinated C fibers sensory neurons by the central and peripheral nervous systems. Substance P is known as a critical primary responder to most of the extreme stimuli, i.e., specifically those with the ability to destabilize the biological integrity. Hence, SP can be considered as an instantaneous system for defense, stress, healing, etc. SP is known to perform a vital role in neurogenic inflammation and the pathophysiology of acute pancreatitis. Out of these, neurogenic inflammation is responsible for acute interstitial pancreatitis as a result of oedema. SP binds itself to the G-protein coupled neurokinin-1 receptor and causes plasma leakage, cell proliferation, and invasion resulting in pancreatic cancer. SP along with comparable neuropeptides seems to be crucial targets with the capability of satisfying several unfulfilled medical requisites. This review article mainly focuses on compiling the available evidence to show that SP could be a novel therapeutic target for pancreatic diseases, and more exploration into the SP signaling pathways is the call of the hour.