Open AccessArfgengur skortur í ræsisameindum lektínferils komplímentvirkjunar
Author(s) -
Björn Rúnar Lúðvíksson,
Helga Bjarnadóttir
Publication year - 2010
Publication title -
læknablaðið
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.147
H-Index - 12
eISSN - 1670-4959
pISSN - 0023-7213
DOI - 10.17992/lbl.2010.10.319
Subject(s) - ficolin , lectin pathway , mannan binding lectin , complement system , collectin , lectin , biology , alternative complement pathway , immunology , immune system , antibody opsonization , classical complement pathway , complement component 2 , innate immune system , antibody , opsonin
The complement system is an important immune system. Its activation results in membranolytic elimination of microbes and opsonization. The classical, alternative and lectin pathways (LP) activate complement. Either mannan-binding lectin (MBL), ficolin-1, ficolin-2 or ficolin-3 initiate the LP through associated serine protease (MASP-2) after binding to microorganisms'surface carbohydrate patterns. Genetic polymorphisms behind MBL deficiency are rather common. Numerous studies indicate that MBL deficiency is a risk factor for invasive and recurrent infections, especially when other immune systems are immature, deficient or compromised. Research in ficolins is limited but last year ficolin-3 deficiency was described. This review focuses on these recently WHO defined immunodeficiencies.