Open AccessPharmacovigilance in Neuroscience
Author(s) -
María-Pilar Sánchez-de-Paz,
Gustavo Da-Prat-de-Magalhaes,
Santiago Isa,
Victoria Aldinio,
Andres Norberto-Latella,
Emilia Mabel-Gatto,
Galeno Rojas
Publication year - 2021
Publication title -
journal of applied cognitive neuroscience
Language(s) - English
Resource type - Journals
ISSN - 2745-0031
DOI - 10.17981/jacn.2.1.2021.04
Subject(s) - pharmacovigilance , medicine , observational study , neurology , drug reaction , adverse effect , adverse drug reaction , intensive care medicine , pediatrics , drug , pharmacology , psychiatry
Background: Adverse drug reactions (ADRs) have a high impact on morbidity and mortality of the population, becoming a public health issue. Studying and publishing about these is referred as pharmacovigilance.Objective: To describe and compare the adverse reactions produced by drugs of nervous system action (CNS-D) and neurological ADRs produced by drugs of systemic action (Sys-D). To further develop the need of reporting adverse reactions. Methods: An observational, cross-sectional, retrospective study performed on a database of neurological consultations which took place at the Neurology department. Patients meeting the inclusion criteria were selected and divided into two groups: Sys-D and CNS-D. Demographic and neurological variables were analyzed. Parametric and non-parametric statistics were used according to distribution. The Naranjo Algorithm (NA) was used to define causality.Results: 71 ADRs were described, from which 63.38% (n=45) were produced by CNS-D, especially antiepileptics by 47% (n=21) and psycholeptics by 44%. Of the total, 36.62% (n=26) were caused by Sys-D, such as antineoplastics (n=9) and antibiotics (n=9), being Cefepime the most frequent. The diagnosis of ADRs caused by a Sys-D was delayed prolonging hospitalization (p 0.05) due to a lower NA score (p 0.003) compared to the CNS-D group.Conclusion: Multiple frequently used drugs of systemic action, such as antineoplastics and antibiotics, generate neurological adverse effects. From our analysis, it was presumed that the suspicion of a neurological ADR caused by these drugs was scarce, thus causing a higher morbidity for the patient.