Open AccessPredictors of favorable response to implanted of ventriculoperitoneal shunt in patients with idiopathic normal pressure hydrocephalus
Author(s) -
Mario Ricciardi,
Ismael Calandri,
Lucas Alessandro,
Mauricio Farez,
Juan F. Villalonga,
Martin Fausti,
Frida Herrmann,
Allegri Ricardo
Publication year - 2020
Publication title -
journal of applied cognitive neuroscience
Language(s) - English
Resource type - Journals
ISSN - 2745-0031
DOI - 10.17981/jacn.1.1.2020.10
Subject(s) - medicine , hydrocephalus , neurosurgery , shunt (medical) , homogeneous , univariate analysis , intracranial pressure , retrospective cohort study , normal pressure hydrocephalus , surgery , multivariate analysis , disease , dementia , physics , thermodynamics
The indication of a ventriculoperitoneal shunt (VPS) is discussed in patients with idiopathic normal pressure hydrocephalus (iNPH), due to the heterogeneity of the response to treatment and the risks involved in neurosurgery. Objective: To search for clinical factors and complementary studies in order to determine predictors of a favorable response to the VPS placement in patients with iNPH. Methodology: A retrospective study of patients with probable iNPH (according to international guidelines) treated with VPS assisted in a neurological clinic from January 2014 to January 2017 was conducted. A univariate statisticalanalysis of the variables considered as possible prognostic factors was performed. Results: 58 patients were included. Women presented 3.68 times more chances of improvement after the VPS (p=0.019). Good response to the gait test was associated with better response to the VPS (p=0.024). Conclusions: Female sex and good response to the gait test could be considered as predictors of a favorable response to the VPS placement in patients with iNPH. A prospective study is necessary to achieve a homogeneous diagnostic evaluation and a more extensive longitudinal follow-up to evaluate the clinical evolution in this group of patients.