Open AccessInfluence of mechanical injury on glutathione redox-system state in bone marrow of rats
Author(s) -
I. A. Bogdanova,
А. М. Герасимов
Publication year - 1995
Publication title -
vestnik travmatologii i ortopedii imeni n.n. priorova
Language(s) - English
Resource type - Journals
eISSN - 2658-6738
pISSN - 0869-8678
DOI - 10.17816/vto99593
Subject(s) - glutathione , glutathione reductase , bone marrow , chemistry , antioxidant , biochemistry , enzyme , biology , glutathione peroxidase , immunology
Dynamics of activity of glutathione: dehydroascorbate oxyreductase, glutathione peroxydase, glutathione reductase was studied in bone marrow of rats with closed bone fractures during different terms after injury infliction. On day 30 of traumatic disease the activity of glutathione: dehydroascorbate oxyreductuse, calculated jn 1 mg DNA, decreased on 27% that increased the sensitiveness of bone marrow cells to the deficit of ascorbinic acid. The detected stability of glutathione reductase showed the possibility of glutathione application in pharmcotherapy of traumatic disease.