Open AccessClinical use of bisphosphonates
Author(s) -
С. С. Родионова,
E. A. Yuryeva,
А. F. Kolondaev,
T. А. Mashkovskaya
Publication year - 1999
Publication title -
vestnik travmatologii i ortopedii imeni n.n. priorova
Language(s) - English
Resource type - Journals
eISSN - 2658-6738
pISSN - 0869-8678
DOI - 10.17816/vto98442
Subject(s) - divalent , chemistry , chelation , bone remodeling , medicine , biochemistry , dentistry , pharmacology , organic chemistry
In the treatment of bone tissue pathology associated with a violation of its metabolism, drugs belonging to the class of bisphosphonates have been increasingly used in the last decade. Bisphosphonates are synthetic analogs of pyrophosphoric acid containing, instead of the chemical bond [P-O-P], which undergoes rapid decay in the body, a non-hydrolyzable bond [P-C-P]. This prevents the drugs from breaking down when taken per os, but since they are chelators, it is recommended to take them on an empty stomach to prevent binding to divalent ions.