Study of Biocompatibility and Antibacterial Properties of Argentum-Tricalcium Phosphate In Vivo | Zendy

V. E Khon | Zendy; N. V. Zagorodniy | Zendy; Vasily Mamonov | Zendy; Е Н Гласко | Zendy; Н. В. Петракова | Zendy; A. N. Shal’Nev | Zendy; T. Ya. Pkhakadze | Zendy; V. C. Komlev | Zendy

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Study of Biocompatibility and Antibacterial Properties of Argentum-Tricalcium Phosphate In Vivo

Author(s) -

V. E Khon,

N. V. Zagorodniy,

Vasily Mamonov,

Е Н Гласко,

Н. В. Петракова,

A. N. Shal’Nev,

T. Ya. Pkhakadze,

V. C. Komlev

Publication year - 2014

Publication title -

n n priorov journal of traumatology and orthopedics

Language(s) - English

Resource type - Journals

eISSN - 2658-6738

pISSN - 0869-8678

DOI - 10.17816/vto20140356-61

Subject(s) - biocompatibility , in vivo , femur , antibacterial activity , bone marrow , subcutaneous tissue , in vitro , phosphate , chemistry , biomedical engineering , materials science , nuclear chemistry , medicine , surgery , pathology , biology , bacteria , biochemistry , organic chemistry , genetics , microbiology and biotechnology

Study of biocompatibility and antibacterial properties of argentum-containing tricalcium phosphate (TCPh) with various degree of substitution by argentum (TCPh-Ag) was performed on rat model. Biocompatibility was studied using subcutaneous implantation of TCPh-Ag (0.5). Antibacterial properties were studied in 5 subgroups (A-E), 5 animals in every group. At first step a distal femur defect was formed and infected by 24-hours cultures of clinical isolates of methicillin-resistant S. aureus. Second step (subgroups B-E) consisted of revision intervention with implantation of either TCPh or TCPh-Ag with various degree of substitution by argentum (0.04, 0.2 and 0.5) into infected defect. Histologic examination of tissue samples with subcutaneous implantation of TCPh-Ag (0.5) showed the absence of inflammatory and rejection reactions that was indicative of study material biocompatibility. Optimim degrees of Ag substitution were 0.2 and 0.5 that provide high antibacterial activity at monotherapy of femur bacterial infection in rats with minimum pronounced toxic effect on the surrounding tissues and bone marrow.

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