Neutrophils Activation in the Development of Early Complications after Total Joint Replacement

In 22 patients who underwent total joint replacement due to bone lesions blood neutrophils (integrine and immunoglobulin receptors) were studied before and after operations. All patients were divided into two groups: patients with favourable postoperative course and patients with prolonged course. In patients with favourable postoperative course the decrease of active neutrophils was observed after operation and that tendency lasted up to the 710 day, then that index gradually increased to initial level. On the contrary, in patients with prolonged postoperative course the level of active neutrophils increased on the 1-3 day and repeated increase was noted on the 7-10 day. That increase was accompanied by the increase of exudate volume in endoprosthetic region. Detection of prolonged postoperative course with the increase of active neutrophils gives the base to the use of medicines reducing the accumulation of neutrophils in endoprosthetic region as well as the drugs inhibiting their injuring effect on the surrounding tissues.