Open AccessChanges of intestinal microbiota and ivabradine biotransformation in rats after alcohol introduction
Author(s) -
Б. Е. Толкачев,
Е. И. Морковин,
Liliya Petrovna Knyshova,
Anatoly Trofimovich Yakovlev,
А. В. Стрыгин
Publication year - 2017
Publication title -
samarskij naučnyj vestnik
Language(s) - English
Resource type - Journals
eISSN - 2782-3016
pISSN - 2309-4370
DOI - 10.17816/snv201763108
Subject(s) - biotransformation , ivabradine , dysbiosis , gut flora , metabolite , pharmacology , excretion , medicine , physiology , biology , immunology , biochemistry , heart rate , enzyme , blood pressure
The role of intestinal microbiota in progress of many pathological processes is discussed in recent publications. It was shown that the continuous intestinal dysbiosis, including the increased bacterial growth syndrome, affects the digestion and the biotransformation of xenobiotics. Intestinal microbiota provokes metabolic failures leading to severe diseases acting via several mechanisms. Alcohol is found to be a common dysbiotic factor and toxic agent affecting the systems of biotransformation. This study was to estimate the associations between the intestinal microbiota and the biotransformation of ivabradine, CYP3A4 substrate, in rats during the chronic alcohol intake. The study used 30 male Wistar rats divided into two groups control and experimental, administrated 15% ethanol as a sole water supply during 40 days to model the chronic alcohol intake. The decrease of bifido- and lactobacterium spp. found in experimental group correlated with excretion and metabolic ratio of ivabradine metabolite and ivabradine in urine. These findings demonstrate the participation of intestinal microbiota in the metabolism of ivabradine after oral introduction.