Open AccessReciprocity between muscarinic and nicotinic cholinoreactive structures of liver tissue in conditions, in substrates and in products of free radical oxidation of liver lipids in 5-day period of cooling in rats
Author(s) -
Viktor I. Tikhanov,
Тиханов Виктор Иванович
Publication year - 2019
Publication title -
obzory po kliničeskoj farmakologii i lekarstvennoj terapii
Language(s) - English
Resource type - Journals
eISSN - 2542-1875
pISSN - 1683-4100
DOI - 10.17816/rcf17351-58
Subject(s) - hexamethonium , pilocarpine , chemistry , atropine , endocrinology , lipid peroxidation , nicotine , medicine , nicotinic agonist , neostigmine , period (music) , cholinesterase , biochemistry , antioxidant , receptor , physics , psychiatry , acoustics , epilepsy
The effects of administration of cholinotropic agents (neostigmine, hexamethonium, pilocarpine, atropine, nicotine) on liver tissue after 5-day period of cooling of rats were compared. The analysis of the conditions inducing lipid peroxidation (LPO), the analysis of the substrate components of the LPO in liver, and the evaluation of the LPO products content in 5-day period of cold loads were made. The data obtained indicate on the contradirectory effects when pilocarpine and nicotine were administered to animals, as well as after administration of atropine and hexamethonium to animals. There was the similar effects after administration of both pilocarpine and hexamethonium and both nicotine and atropine in conditions of activated LPO assessed by substrate components of LPO in the liver after 5-day cooling. On the basis of these results, a hypothesis of reciprocity between muscarinic and nicotinic cholinoreceptors located on the plasma membrane of hepatocytes in the LPO processes of the liver during the period of cold loads has been formulated.